[Kroy]

Super cool. Cancer patient needs new windpipe so they created a glass replica of his organ and coated it with stem cells harvested from his own bone marrow. The end result is he has a fully functional synthetic windpipe his body will not reject since it's composed of his own cells. We need stem cell research.


http://www.bbc.co.uk/news/health-14047670

Scientists in London created an artificial windpipe which was then coated in stem cells from the patient.

Crucially, the technique does not need a donor, and there is no risk of the organ being rejected. The surgeons stress a windpipe can also be made within days.

The 36-year-old cancer patient is doing well a month after the operation.

Professor Paolo Macchiarini from Italy led the pioneering surgery, which took place at the Karolinska University Hospital.

In an interview with the BBC, he said he now hopes to use the technique to treat a nine-month-old child in Korea who was born with a malformed windpipe or trachea.

Professor Macchiarini already has 10 other windpipe transplants under his belt - most notably the world's first tissue-engineered tracheal transplant in 2008 on 30-year-old Spanish woman Claudia Costillo - but all required a donor.

Indistinguishable
The key to the latest technique is modelling a structure or scaffold that is an exact replica of the patient's own windpipe, removing the need for a donor organ.

To do this he enlisted the help of UK experts were given 3D scans of the 36-year-old African patient, Andemariam Teklesenbet Beyene. The geology student currently lives in Iceland where he is studying for a PhD.

Using these images, the scientists at University College London were able to craft a perfect copy of Mr Beyene's trachea and two main bronchi out of glass.

This was then flown to Sweden and soaked in a solution of stem cells taken from the patient's bone marrow.

After two days, the millions of holes in the porous windpipe had been seeded with the patient' own tissue.

Dr Alex Seifalian and his team used this fragile structure to create a replacement for the patient, whose own windpipe was ravaged by an inoperable tumour.

Despite aggressive chemotherapy and radiotherapy, the cancer had grown to the size of a golf ball and was blocking his breathing. Without a transplant he would have died.

During a 12-hour operation Professor Macchiarini removed all of the tumour and the diseased windpipe and replaced it with the tailor-made replica.

The bone marrow cells and lining cells taken from his nose, which were also implanted during the operation, are able to divide and grow, turning the inert windpipe scaffold into an organ indistinguishable from a normal healthy one.

And, importantly, Mr Beyene's body will accept it as its own, meaning he will not need to take the strong anti-rejection drugs that other transplant patients have to.

Professor Macchiarini said this was the real breakthrough.

"Thanks to nanotechnology, this new branch of regenerative medicine, we are now able to produce a custom-made windpipe within two days or one week.

"This is a synthetic windpipe. The beauty of this is you can have it immediately. There is no delay. This technique does not rely on a human donation."

He said many other organs could be repaired or replaced in the same way.

A month on from his operation, Mr Beyene is still looking weak, but well.

Sitting up in his hospital bed, he said: "I was very scared, very scared about the operation. But it was live or die."

He says he is looking forward to getting back to Iceland to finish his studies and then returning to his home in Eritrea where he will be reunited with his wife and young family, and meet his new three-month-old child.

He says he is eternally grateful to the medical team that has saved his life.

[E92TTKING]

good but very rare and most people will reject the replica organ

[Kiemyster]

I cant wait for them to start printing organs. soon enough, its coming

[Kroy]

Originally Posted by greek335xi

good but very rare and most people will reject the replica organ

this sounded like a very new procedure though. they used the patient's own stem cells to personalize the replacement organ. end of article said the patient was a bit weak a month after surgery but was in stable health. i'm clearly no expert on the subject, but would assume using one's own stem cells would help prevent the body rejecting the new organ.

[tHegeRm]

Seen the process on How It's Made, pretty cool future science stuff right here.

[Seminole]

Originally Posted by greek335xi

good but very rare and most people will reject the replica organ

I thought the whole point of stem cells is that your body doesn't reject it because it is your own cells, not a foreign object.

BTW, LOL! What did greek do to get banned?

[CollinsE90]

Originally Posted by Seminole

I thought the whole point of stem cells is that your body doesn't reject it because it is your own cells, not a foreign object.

BTW, LOL! What did greek do to get banned?

who cares

[BlackMoupe]

Glass? Wonder what happens in an injury. Amazing feat though.

[aut0sh0cker]

Originally Posted by SSKE92

Glass? Wonder what happens in an injury. Amazing feat though.

the glass model just acts as a scaffolding for the stem cells to grow on and shape properly

[Kiemyster]

this is what the cool kids are talking about.

^^^ where the fuck do i sign up?

[Kiemyster]

ohh, yeah, and let me just point out, this shit is powered by windows. not mcfapple.

[E90SoFlo]

Originally Posted by Kiemyster

ohh, yeah, and let me just point out, this shit is powered by windows. not mcfapple.

Yes but the video was edited on a apple

[Kiemyster]

Originally Posted by E90SoFlo

Yes but the video was edited on a apple

but video editing is new stuff these days. the big boys use windows for the heavy duty shit, homie